Dados do Trabalho

Título

Venous thromboembolism in in-hospital cirrhotic patients. A systematic review

Resumo

ABSTRACT
Introduction: Liver cirrhosis prone patients to a higher risk for hospitalization. The present review aimed to assess the risk of thromboembolism and its burden in in-hospital cirrhotic patients. Methods: A systematic review (PROSPERO: CRD42021256869) was conducted in PubMed, Embase, Cochrane, Lilacs, and a manual search of references, evaluating studies that compare cirrhotic patients with venous thromboembolism (VTE) vs. cirrhotic patients without VTE, or studies that compare cirrhotic patients vs. non-cirrhotic patients. No restrictions were set for the date of publication or language. The last search was conducted in June 2021. Results: After selection, 17 studies were finally included from an initial search of 5323 articles. The liver chronic disease etiologies comprise viral, alcohol, autoimmune, NASH (non alcoholic steatohepatitis ), cryptogenic, hemochromatosis, cholestasis, and drug-related. The included studies were conflicted regarding the outcomes VTE, pulmonary embolism, bleeding. Patients with cirrhosis associated with VTE had prolonged length of hospital stay, and patients with cirrhosis had higher risk for portal thrombosis. Conclusion: In-hospital cirrhotic patients are a heterogeneous group of patients that may present both thrombosis and bleeding risk. Clinicians should have extra caution to apply both prophylactic and therapeutic anticoagulation strategies.



Keywords: Liver cirrhosis; venous thrombosis; Systematic review

Área

Gastroenterologia - Fígado