Dados do Trabalho

Título

Analysis of clinical and volumetric parameters of white matter lesions identified by magnetic resonance imaging in women with migraine

Resumo

Introduction: Migraine is a very prevalent primary headache characterized by attacks of
pulsatile, unilateral pain, associated with nausea, photo and phonophobia. It is believed that
repeated headache episodes throughout life may cause structural changes in the central
nervous system, especially in those patients with a high frequency of attacks and with aura
subtype. White matter lesions (WML) are the most reported structural changes in
neuroimaging studies. Objective: This work uses volumetry and voxel-based morphometry
(VBM) techniques to analyze WML in migraineurs. Methods: Sixty volunteers from a tertiary
headache center were selected and divided equally into four groups: episodic migraine
without aura (MoA), episodic migraine with aura (MA), chronic migraine (CM) and controls
(CG). The participants performed 3.0T magnetic resonance imaging (MRI). WML variables
were compared between groups and about the clinical characteristics of the sample.
Results: There were no differences in WML variables between groups. There was a positive
weak correlation between age and the number and total volume of WMLs, which persisted in
the comparison categorized by size and location by brain lobe, except for the occipital lobe.
Disease duration was positively correlated with the number and total volume of WML, but
when the variable was controlled by age; the correlation was significant only for the insular
lobe. Aura frequency was relevant for the frontal and temporal lobe WMLs. There was no
statistically significant correlation with attack frequency, pain intensity and use of
prophylactic medication. Conclusion: The type of migraine does not influence the formation
of LSBs. Number and volume of WML were correlated with insula, and the presence of
frontal and temporal lobe WML were correlated with aura frequency.