Dados do Trabalho

Título

SLEEP DISORDERS IN CONGENITAL ZIKA VÍRUS SYNDROME

Resumo

Introduction: Congenital Zika virus syndrome (CZVS) sleep characteristics in patients are still poorly studied, with only one study in which the Brief Infant Sleep Questionnaire (BISQ) was carried out, that shows that 34.1% of CZVS were defined as poor sleepers. No previous study performed electrophysiological assessment of sleep.
Purpose: The aim of this study was to clinically characterize sleep disorders in a case series of CZVS patients, correlating these findings with disease features and polysomnographic (PSG) results.
Methods: This is a non-randomized, cross-sectional study with consecutive inclusion of confirmed CZVS. The evaluation was performed with PSG and the characteristics of sleep were evaluated using Sleep Disturbance Scale for Children (SDSC) and BISQ.
Results: Ten patients were evaluated, with a mean age of 4,6 years, seven male (7/10). Eighty percent of the patients present a SDSC score more than 39, therefore, demonstrate sleep disturbances and 20% clinically relevant. The BISQ sleep pattern analysis showed that 10% of children were defined as poor sleepers, 10% had more than 3 wakes per night and 80% had nocturnal wakefulness period more than 1 hour.
Polysomnography evaluation: Two patients were not evaluated in the polysomnography due to technical difficulties (exam duration and was no signal capture in the nasal cannula). Mild sleep apnea was detected in 5 patients and moderate in 2 patients, of these 2 with central and obstructive apnea. Mild desaturation in 5 patients and severe in 1 patient. Increase in sleep latency was documented in 5 children, normal in 2 and reduction in 1.. Presence of periodic movement of members, with a PLM index of 29.8/h, in one patient. All showed reduced REM sleep, which was not detected in 1 patient.
Conclusion: The frequency of sleep disorders in the population of children with confirmed CZVS is very high, being important the evaluation through polysomnography in this population.

Palavras Chave

Zika virus, Congenital zika virus syndrome, sleep disorders, polysomnography