Dados do Trabalho

Título

Prevalence of depression in patients with relapsing remitting or primary progressive Multiple Sclerosis.

Resumo

Background: Multiple sclerosis is a demyelinating autoimmune disease of the central nervous system (CNS). May cause visual, motor, cognitive and dysautonomic symptoms. The main clinical presentations are relapsing-remitting (RRMS) or primary-progressive (PPMS). Due to the debilitating symptoms and the unpredictability of new outbreaks, in addition to the neurological dysfunctions associated with the condition, MS patients are susceptible to depression, which can compromise the individual's quality of life and prognosis. Objective: To compare the prevalence of depression in patients with RRMS or PPMS. Methodology: Cross-sectional study, single-center, conducted with multiple sclerosis patients at the Magalhães Neto ambulatory in Salvador from august 2021 to may 2022. Patients were asked about their clinical history, whether they had a diagnosis of depression were also measured by the Hospital Anxiety and Depression Scale (HADS). Results: Of the 178 patients that were enrolled, 89.3% (n - 159) had RRMS, 10.6% (n - 19) had PPMS. Of the 159 RRMS patients, 22,6% (n - 36) had depression, 76,7% (n - 122) did not. Of the 19 PPMS patients, 47,3% (n - 9) had depression, 52.6% (n - 10) did not. The HADS was applied in 105 RRMS patients. 74.2% (n - 78) had a normal value of 0-7, 8.6% (n - 9) had a borderline value of 8-10 and 17.14% (n - 18) had an abnormal value of 11-16. The HADS was applied in 15 PPMS patients. 60% (n - 9) had a normal value, 20% (n - 3) had a borderline value and 20% (n - 3) had an abnormal value. Conclusion: Patients with PPMS had a higher prevalence of depression and abnormal values ​​on the HADS compared to patients with RRMS. The patient with PPMS presents progressive worsening, with the accumulation of neurological deficits over time, in addition, there are few medications available for these patients, leading to a higher occurrence of depression in this group.

Palavras Chave

multiple sclerosis, depression, primary-progressive, relapsing-remitting

Área

Neuroimunologia