Dados do Trabalho

Título

INFLUENCE OF NON-INVASIVE NEUROMODULATION ON FOOD INHIBITION, EXECUTIVE FUNCTIONS AND BIOCHEMICAL PARAMETERS OF INFLAMMATION AND OXIDATIVE STRESS

Resumo

INTRODUCTION: The various pathologies that occur with the metabolic disorder promote chronic inflammation, leading to impairment of the integrity of the blood-brain barrier, which may affect cognitive functions. PURPOSE: to correlate markers of antioxidant activity, inflammation and executive functions with tDCS in healthcare professionals. METHODOLOGY: randomized, parallel, double-blind clinical trial. The target population consisted of health professionals from the clinical staff of a university hospital. The following instruments were applied: Intense Food Cravings – Trait and State questionnaires, Brazilian Craving-Related Food Inventory, Three-Factor Eating Questionnaire, digit span test; Stroop Test of Colors and Words, Victoria version; Trial Making Test). Determinations of thiobarbituric acid reactive species (TBARS) and lipid peroxidation biomarkers were also performed. RESULTS AND DISCUSSION: A statistically significant reduction was found in QDIC-T values ​​(p<0.0074**); FCI-Br (p<0.0005**); Digit span (forward order: p<0.007**; reverse order: p<0.01**); TSCP (conditions 1: p<0.003**; 2: p<0.006** and 3: p<0.008**); Trail Making Test (A: 0.05* and B: 0.007**) in the tDCS group when compared to the sham group. In this research, we observed that the application of tDCS triggered statistically significant changes in: women with a mean age predominantly between 31 and 40 years; middle-class income; high level of education; overweight and without previous infection by Covid-19; regarding: traits of food cravings, especially for sweets, fatty foods and traditional meal, executive functions. CONCLUSION: The use of tDCS influences the reduction of food cravings and the reduction of reaction time and the processing of executive functions, although there are no significant changes in brain bioenergetics to the point of impacting the biochemical parameters of inflammation.

Palavras Chave

Obesity Management; Neuropsychology; Rehabilitation; Transcranial Direct Current Stimulation.