Dados do Trabalho

Título

COMORBITIES ASSOCIATED WITH EPILEPSY IN PEDIATRIC POPULATION

Resumo

INTRODUCTION: The presence of comorbidities epilepsy in the pediatric population is routinely evaluated in the follow-up, in such a way that the associated clinical condition can affect quality of life, response to treatment or even mortality. Proper diagnosis and treatment of comorbidities can influence the appropriate control and management of epilepsy. OBJECTIVES: To assess the prevalence and types of comorbidities (intellectual disability, migraine, behavioral changes and sleep Disorders); Analize the association of comorbidities with types of seizures and use of anti-seizures medications. METHODS: Retrospective study, carried out in the Child Neurology outpatient sector of a University Hospital from April 2020 to May 2022. Data were distributed in frequency, and the chi-square tests of independence were performed to verify the association between variables and Fisher's exact test, using IBM SPSS software, and adopted significance of 5%. RESULTS: The sample consisted of 282 patients with epilepsy (50.7% male; 49.3% female). The most prevalent age group, when the disease started, was older than 11 years (31.2%), followed by those younger than 2 years (30.9%). Focal seizures in 77.7% of the sample, indeterminate seizures in 11.3% and generalized seizures in 11.3%. Some degree of intellectual disability represented 60% of the sample, and significant association with indeterminate epilepsy (53.1%; p=0.007). Temporal lobe seizures ocurred in 21.6%, with seizures with behavioral arrest in 67.2%; the frontal crisis corresponded to 12%. In addition, the occurrence of temporal lobe crisis was associated with some degree of intellectual deficit (62.3%) with good correlation with the severity of the deficit (p<0.001). The presence of frontal seizures was more associated with the use of two or more medications (50%) compared to the group with other seizures (26.7%; p=0.021). Patients with migraine made up 34% of the sample, being more frequent in the non-frontal seizures group (p=0.017) or using more medications (p=0.006). Behavior disorders were observed in 21% of the sample, with a higher prevalence in the group that used 2 or more medications (p=0.026). CONCLUSION: The association of many common psychiatric and somatic conditions is increased in epilepsy. The use of 2 or more anti-seizures medications should reflect not only dificult in epilepsy control. These findings may have implications in diagnosis and management of epilepsy and coexisting conditions.

Palavras Chave

Epilepsy. Comorbidities. Migraine. Intellectual deficit. Pediatric population.

Área

Epilepsia