Dados do Trabalho

Título

Cognitive decline and possible biomarkers in Rheumatoid Arthitis: a systematic review.

Resumo

Introduction: Cognitive dysfunction is a frequent complaint in patients with autoimmune disease and associated with impaired quality of life and loss of functionality. During the last years, a growing number of studies have investigated the link between cognitive dysfunction and Rheumatoid Arthritis (RA), highlighting the potential pathogenic role of several clinical, psychological, and biological factors.
Objective: Considering the scarce literature on neuropsychiatric manifestations in RA, as well as the lack of serological markers that can help in clinical practice, we aimed to investigate serological and CSF biomarkers in humans, and its association with cognitive dysfunction in patients with RA.
Methods: We performed a systematic review using PRISMA protocol. A systematic search was conducted in the PubMed/Medline, Embase, LILACS, Scopus and Google Scholar databases from inception up to November 2021.The inclusion criteria for studies were defined based on the participants involved, type of exposure, type of comparison group, outcome of interest and study design.
Results: Five original studies were included, which provided data from 428 participants. The studies included plasma proteins, autoantibodies, cytokines, interleukins, neurotrophic factors and lymphocyte subpopulations. Among plasma proteins, SHH was increased and TTR was reduced in patients with mild cognitive impairment; Anti -MBP and Anti-MOG negatively correlated with memory, executive function and attention. S100β negatively correlated with memory and executive functions; some lymphocyte subpopulations positively correlated with attention, memory, and executive functions. IL-2, IL-4, IL-6 and TNF