Dados do Trabalho

Título

A Geographical Study on Amyotrophic Lateral Sclerosis in Rio Grande do Norte, Brazil, from 2005 to 2018.

Resumo

Introduction: Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disorder with variable incidence and prevalence worldwide. However, clinical-epidemiological studies on ALS are scarce in Brazil. Objective: this study investigated whether ALS incidence had uniform spatial distribution in a population-based cluster analysis in Rio Grande do Norte state (Brazil), from 2005 to 2018. Methods: new cases of ALS were identified in a database of the ALS multidisciplinary care centre of the Onofre Lopes University Hospital in Natal (Rio Grande do Norte, Brazil). Approaches were based on incidence (empirical Bayes estimator and Moran's I analysis) and cluster analyses (Moran scatter plot and spatial correlogram). Results: a total of 177 patients (59% males) participated in the study; mean age of ALS onset was 57 years. Mean annual incidence of ALS was 0.3769 per 100,000 inhabitants (95% confidence interval of 0.0889), higher in males than in females (0.4516 per 100,000 vs. 0.3044 per 100,000). According to spatial statistics, patients were homogeneously distributed throughout the studied area. Conclusion: a low estimate was observed compared with other populations. Results did not indicate areas of increased risk or significant spatial geographic dependence, suggesting a random ALS incidence in Rio Grande do Norte.

Palavras Chave

amyotrophic lateral sclerosis, motor neuron disease, epidemiology, incidence, spatial analysis