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Título

ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH PARKINSON'S DISEASE: A TERTIARY CARE CENTER EXPERIENCE IN NORTHEASTERN BRAZIL

Resumo

INTRODUCTION: Motor and non-motor symptoms in Parkinson’s Disease (PD) usually progress and cause physical, mental and social impairment, affecting the individual's level of functionality and patients’ quality of life (QoL). OBJECTIVE: To evaluate and to describe QoL in PD patients. METHOD: Between May 2021 and January 2022, a cross-sectional study was done at a Movement Disorders clinic in Teresina/PI. QoL assessment was done using the Parkinson's Disease Questionnaire 39 (PDQ39) in Brazilian Portuguese version. We also analyzed medical records to obtain demographics, HOEHN and YAHR (HY) Scale scores and Levodopa Equivalent Daily Dose (LEDD). Patients were categorized according their age range. Data was analyzed with RStudio software. Regression test was performed with disease duration and PDQ-39 domains, considering p<0.05 as significant. RESULTS: During the period, data were collected from 93 patients, most of whom were male (63.4%) and aged between 65 and 74 years (41.9%). As for the duration of the disease, most had between 5 and 10 years of evolution (44.1%) and the LEDD was between 350 and 700 (33.3%). The mean LEDD of the general population of our patients was 677.37 (± 372.07). On the HY Scale, most were between stages 1 and 3 (91.4%). Regarding the PDQ-39, 4 out of the 8 domains had means above 50, and therefore, a worse perception of quality of life, namely Mobility (71.93/±30.24), Body discomfort (70.60/±23.71), Activity of daily living (ADL) (62.95/±29, 24) and Emotional well-being (54.25/±29.63). The domain with the lowest score in the general population of this study was Social Support (34.41/±13.91). When comparing the averages of men and women separately, the domains with the greatest scores were also Mobility, Body Discomfort, ADL and Emotional Well-being. However, in all these domains, women had greater scores when compared to men. In addition, after regression test, there was statistical significance in the Mobility (p=0.023), ADL (p=0.016) and Communication (p=0.006) domains in patients with more than 20 years of disease duration. CONCLUSION: It was noted that both motor and non-motor aspects may be related to a worse perception of QoL by these patients. In addition, other individual characteristics, such as sex, lead to different perspectives on quality of life. Thus, it is necessary to direct integrated care strategies aimed at the support and treatment of people with Parkinson's Disease, taking into account their individualities.

Palavras Chave

Parkinson's Disease; Quality of Life; Movement disorders

Área

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