Dados do Trabalho

Título

What Causes the Increased Frequency of Ischemic Cerebrovascular Accident Cases in Patients Infected with SARS-CoV-2 Virus? A Systematic Review.

Resumo

Introduction: The hypercoagulant characteristic of Covid-19 is a factor of high impact in the lives of affected patients. The syndrome hypercoagulation promotes cases of ischemic stroke, which occurs when there is blockage or rupture of a cerebral artery, even after the passage of high waves of contamination, however, specific studies of the characteristic are still insufficient, making treatment and prevention of the problem inefficient.
Objective: To analyze the causes of the prevalence of ischemic stroke cases in patients contaminated by the SARS-CoV-2 virus.
Method: The results established by incidence studies published from the year 2017 to 2022 with the keywords: "SARS-CoV-2", "Covid-19", "Ischemia" and "Stroke" in the MEDLINE and PUBMED databases were selected and analyzed for this systematic review, excluding publications that portrayed patients who were contaminated with the SARS-CoV-2 virus only after presenting ischemic conditions and publications that portrayed cases of ischemia that were not classified as cerebral ischemia. Their characteristics and results were analyzed to determine the probable reasons for the increase in cases of ischemic stroke in infected persons.
Results: Studies have stated that cases of ischemic stroke in patients infected with the SARS-CoV-2 virus are more common in patients with severe infections and in patients with preexisting cases of ischemic risks. Research also shows that cases of stroke accompanied by Covid-19 are associated with cases of endotheliopathy, systemic inflammatory responses, and a high Von Willebrand Factor.
Conclusion: The increase in ischemic stroke cases is shown to be related to the hypercoagulant characteristic of the SARS-CoV-2 infection, a characteristic influenced by points such as a high Von Willebrand Factor. Despite the presentation of a number of probable motivations, there is no study to guarantee that new factors may not have a major influence on the increase in cases. New studies are also needed to evaluate if there is a predominance of cerebral ischemia or a homogeneous distribution among other types of ischemia due to the influence of the virus and its characteristics.

Palavras Chave

SARS-CoV-2; Covid-19; Ischemia; Stroke; Systematic Review.