Dados do Trabalho

Título

Transcranial Magnetic Stimulation for Depressive Symptoms in Patients with Multiple Sclerosis

Resumo

Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord. Up to 50% do MS patients experience depressive disorders. Transcranial Magnetic Stimulation (TMS) has been used for depression. Objectives: To evaluate the effect of TMS on depressive symptoms in patients with MS. Methods: A quantitative study was performed with 20 people diagnosed with multiple sclerosis (13 relapsing-remitting, 4 primary-progressive and 3 secondary-progressive), aged between 33 and 68 years (Mean = 50.0, SD = 10.6 years), 6 men (30%) and 14 women (70%), with EDSS score from 0 to 6.5 (Mean = 4.6, SD = 1.9), time of diagnostic between 1 and 24 years (Mean = 10.0, SD = 7.2 years). The protocol consisted of 10 interventions by TMS (primary motor cortex (Cz): 50 pulses per time, 30 trains, 20seconds of interval, totaling 1500 pulses at 90% of resting motor threshold and left dorsolateral prefrontal cortex (F3): 10Hz, 50 pulses per train, 40 trains, 20 seconds interval, totaling 2000 pulses at 110% of resting threshold) during 10 consecutive working days. For evaluation, an interview was conducted to collect data and applied the BDI (Beck Depressions Inventory) at the beginning and at the end of the stimulations. Results: It was observed that 30% of the participants presented depression. It was found that 65% of participants had improvement in symptoms of depression. However, among those who had depression, 83.3% had improved symptoms. Conclusions: Depression is a substantial health problem in need of novel and effective treatment strategies. TMS is a non-invasive and safe treatment. This preliminary study suggests that TMS has potential for treating depression in people with MS. The promising results encourage the acquisition of additional evidence.

Palavras Chave

Multiple Sclerosis; Depression; Transcranial Magnetic Stimulation.

Área

Neurorreabilitação