XXII Congresso Brasileiro de Oncologia Clínica

Dados do Trabalho


Título

BODY MASS INDEX (BMI) AND SURVIVAL IN A COHORT OF 649 METASTATIC NON-SMALL CELL LUNG CANCER M(NSCLC) PATIENTS (PTS)

Introdução

Obesity (BMI ≥30 kg/m²) is associated with increased risk and mortality of several solid tumors. Nevertheless, obesity has been associated with both a reduced risk of lung cancer and better overall survival of lung cancer pts. In the context of increasing rates of obesity worldwide, the so-called “obesity paradox” has not been completely cleared up and deserves further investigation.

Objetivo

To analyze the relationship between BMI and overall survival (OS) in patients with mNSCLC treated in a Brazilian Cancer Center.

Método

This retrospective study included 648 consecutive mNSCLC pts treated at ACC from January 2007 to September 2020. Clinical-pathological data were collected from electronic medical records. Kaplan-Meier curves, Log-Rank test and Cox regression were used for survival analysis; Cox regression was used for univariate and multivariate analyses. Tests with p<0.05 were considered statistically significant.

Resultado

In 444/648 (85.4%) pts BMI was < 30kg/m² and in 76/648 (14.6%) it was ≥30 kg/m². Baseline characteristics in BMI < 30kg/m² vs ≥30 kg/m² were similar for gender (male: 56.3% vs 59.2%, respectively; p 0.73), smoking status (smoker/former smoker: 68.1% vs 74.7%; p<0.31), histology (non-squamous: 82.7% vs 84.2%; p 0.87), ECOG status (0-1: 84.1% vs 91%; p <0.2), Charlson comorbidity score (7: 47.4% vs 52.9%, respectively; p=0.44), liver metastases (13.3% vs 10.7%, respectively; p=0.66), and brain metastases (32.4% and 34.7%, respectively; p=0.8). Median OS was 16.6 months in non-obese and 25.3 months in obese pts (HR 0.69; 95% IC 0.51 – 0.92; p = 0.01). BMI ≥30 kg/m² was associated with better OS (HR 0.7; 95% CI 0.51-0.96; p=0.025). Cox multiple regression analysis including BMI, ECOG, Charlson score, and histology confirmed BMI as an independent prognostic factor.

Conclusão

Pts with higher BMI, particularly > 30kg/m² (obesity), was associated with improved overall survival compared to non-obese patients, regardless of possible confounder factors.

Palavras-chave

Obesity; Body mass index; Lung cancer

Área

Oncologia - Tumores torácicos

Autores

MARIA FERNANDA BARBOSA DE MEDEIROS, MARIA FERNANDA EVANGELISTA SIMÕES, DEBORA MACIEL SANTANA, CAMILA IASMIN ANDRADE SOUZA, LUCIANA BEATRIZ MENDES GOMES, JOSÉ ÉCIO BATISTA ROSADO JUNIOR, THIAGO BUENO DE OLIVEIRA, MARCELO PETROCCHI CORASSA, VLADMIR CLAUDIO CORDEIRO DE LIMA, HELANO CARIOCA FREITAS