Dados do Trabalho

Título

BODY MASS INDEX (BMI) AND SURVIVAL IN A COHORT OF 649 METASTATIC NON-SMALL CELL LUNG CANCER M(NSCLC) PATIENTS (PTS)

Introdução

Obesity (BMI ≥30 kg/m²) is associated with increased risk and mortality of several solid tumors. Nevertheless, obesity has been associated with both a reduced risk of lung cancer and better overall survival of lung cancer pts. In the context of increasing rates of obesity worldwide, the so-called “obesity paradox” has not been completely cleared up and deserves further investigation.

Objetivo

To analyze the relationship between BMI and overall survival (OS) in patients with mNSCLC treated in a Brazilian Cancer Center.

Método

This retrospective study included 648 consecutive mNSCLC pts treated at ACC from January 2007 to September 2020. Clinical-pathological data were collected from electronic medical records. Kaplan-Meier curves, Log-Rank test and Cox regression were used for survival analysis; Cox regression was used for univariate and multivariate analyses. Tests with p<0.05 were considered statistically significant.

Resultado

In 444/648 (85.4%) pts BMI was < 30kg/m² and in 76/648 (14.6%) it was ≥30 kg/m². Baseline characteristics in BMI < 30kg/m² vs ≥30 kg/m² were similar for gender (male: 56.3% vs 59.2%, respectively; p 0.73), smoking status (smoker/former smoker: 68.1% vs 74.7%; p<0.31), histology (non-squamous: 82.7% vs 84.2%; p 0.87), ECOG status (0-1: 84.1% vs 91%; p <0.2), Charlson comorbidity score (7: 47.4% vs 52.9%, respectively; p=0.44), liver metastases (13.3% vs 10.7%, respectively; p=0.66), and brain metastases (32.4% and 34.7%, respectively; p=0.8). Median OS was 16.6 months in non-obese and 25.3 months in obese pts (HR 0.69; 95% IC 0.51 – 0.92; p = 0.01). BMI ≥30 kg/m² was associated with better OS (HR 0.7; 95% CI 0.51-0.96; p=0.025). Cox multiple regression analysis including BMI, ECOG, Charlson score, and histology confirmed BMI as an independent prognostic factor.

Conclusão

Pts with higher BMI, particularly > 30kg/m² (obesity), was associated with improved overall survival compared to non-obese patients, regardless of possible confounder factors.

Palavras-chave

Obesity; Body mass index; Lung cancer