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Título

ANALYSIS OF THE GLOBAL SURVIVAL OF A REFERENCE CENTER IN PEDIATRIC NEURO ONCOLOGY DURING 10 YEARS

Resumo

BACKGROUND: Central nervous system (CNS) tumors are the most common malignant neoplasm in children, being the main cause of morbidity and mortality in the pediatric population. At the Barretos Cancer Hospital, we observed a rise in the number of patients diagnosed with central nervous system tumors, which are the main malignant neoplasms among solid tumors. With the low overall survival rate of 20% in the country, there is a need for a multidisciplinary pediatric neuro-oncology group dedicated to better diagnosis and treatment with improved survival and patient care .

AIM: Analyze the overall survival in two periods of patients diagnosed with brain tumor in the pediatric age group (under 18 years old).

METHODS: Retrospective and cross-sectional study, analysis of 445 pediatric patients aged from 0 to 18 years old with a diagnosis of CNS tumor, divided into two periods: January/2000 to June/2013 and August/2013 to July/2019. We evaluated gender, age group, histology, topography, type of treatment (surgery, chemotherapy and/or radiotherapy) and follow-up.

RESULTS: Of the 445 patients with CNS neoplasia, 198 (44.49%) were diagnosed from January/2000 to June/2013 with OS at 2 years of 59.6%, 5 years of 51.5% and 10 years 43.2%. In the second 6-year period, 247 (55.5%) were diagnosed with a 2-year survival of 72.7% and a 5-year survival of 67% with statistical significance (p < 0.0001).

CONCLUSION: This study showed the importance of the team specialized in pediatric neurooncology, bringing significant data to the literature of a developing country.