Dados do Trabalho

Título

MILD COGNITIVE IMPAIRMENT: ARE PRO-INFLAMMATORY CYTOKINE CONCENTRATIONS RELATED TO PHYSICAL FITNESS?

Introdução

Mild cognitive impairment describes individuals who are between preserved cognitive function and dementia, who are more likely to develop Alzheimer's disease. Previously, higher levels of pro-inflammatory cytokines were suggested as predictors of increased risk of progression from mild cognitive impairment to Alzheimer's disease and as we know, physical exercise it is possible to reduce concentrations of pro-inflammatory cytokines. In addition, the practice of physical exercise modulates the individual's aerobic capacity, which is measured by the maximum consumption of oxygen called VO2 max. But the relationship between physical fitness and pro-inflammatory cytokine concentrations remains unknown.

Objetivo

The aim of this study was to investigate whether there is a correlation between V02 max and proinflammatory cytokine levels in elderly people with mild cognitive impairment.

Método

29 elderly people with mild cognitive impairment were evaluated for serum concentrations of cytokines: IL-8 and IL-12. Participants were also evaluated for their physical fitness (VO2 max) through a treadmill exercise test (ergospirometry). Pearson's correlation was used to calculate the correlation between VO2 max and IL-8, but due to the non-parametric distribution of IL-12 data, Spearman's correlation coefficient was used.

Resultados

A moderate correlation was observed between proinflammatory cytokines and VO2 max (IL-8 r = 0.39 and IL-12: r = 0.41, p = 0.02).

Conclusão

Better physical fitness was positively correlated with proinflammatory cytokines in individuals with mild cognitive impairment, which was not expected, as we hypothesized that there was a negative correlation between the variables. But despite the results, other studies show that exercise is also related to increased concentrations of anti-inflammatory cytokines, which are important in reducing neuroinflammation, cognitive dysfunction and neurodegeneration, indicating their potential effect on neuroinflammation. Therefore, further studies are suggested to unravel the impact of physical fitness on pro- and anti-inflammatory cytokine concentrations in populations at risk of Alzheimer's disease.

Palavras-chave

Dementia. Exercise. Interleukin.

Área

Neurociência básica