The research group of Clifford R. Jack Jr., M.D., is engaged in brain imaging research in cognitive aging and Alzheimer's disease and related disorders.  Specific goals are to understand how various imaging measures relate to neuropathology, cognitive, behavior and specific phenotypic abnormalities. All modern brain imaging modalities (amyloid PET, FDG PET, tau PET, anatomic MRI, diffusion imaging, perfusion imaging, task free functional MRI, and quantitative susceptibility mapping) are used along with clinical, psychometric, genetic and neuropathologic information.  The group also serves as the MR center for large multi-site observational and interventional studies including ADNI, DIAN, ARIC, A4, AHEAD, Jackson Heart Study and SCAN.